New Directions in Prostate Cancer Treatment

A type of cancer therapy that delivers radiation directly to cancer cells may represent the newest advance in the treatment of prostate cancer, according to results from a large clinical trial. The trial included participants with a hard-to-treat form of advanced prostate cancer, called metastatic castration-resistant prostate cancer, that had gotten worse despite treatment with standard therapies.

In the study, participants who received the drug, called  177 Lu-PSMA-617, along with other standard treatments lived longer than those who received only standard therapies: a median of 15.3 months versus 11.3 months.

Treatment with  177 Lu-PSMA-617—one of an emerging group of cancer therapies called radiopharmaceuticals—did lead to more side effects. In addition, several deaths were attributed to treatment with the radiopharmaceutical. However, the researchers reported that the most common side effects, such as fatigue and dry mouth, were rarely serious and that participants generally appeared to handle the side effects well. The results from the trial, called VISION, were presented on June 6 at the annual meeting of the American Society of Clinical Oncology (ASCO) and published June 23 in the New England Journal of Medicine.

The study’s findings support making  177 Lu-PSMA-617 a “new treatment option for this patient population,” said the trial’s lead investigator, Michael Morris, M.D., of Memorial Sloan Kettering Cancer Center, during a press briefing at the ASCO meeting.

Several other experts on treating prostate cancer agreed.

Mary-Ellen Taplin, M.D., who specializes in treating prostate cancer at the Dana-Farber Cancer Institute in Boston, called VISION “a very positive trial” and said she believes there will be strong interest among patients and clinicians for 177 Lu-PSMA-617. However, Dr. Taplin, who was an investigator on the trial, also said she was disappointed that adding  177 Lu-PSMA-617 to treatment only improved patient survival by several months. “I had hoped for more,” she said.

177 Lu-PSMA-617 is not yet approved by the Food and Drug Administration (FDA), but Novartis, which manufactures the drug and funded the VISION trial, said that it plans to submit an approval application to the agency later this year.

 

Targeting PSMA: Not Just for Imaging

Like a number of other radiopharmaceuticals,  177 Lu-PSMA-617 has two components: a drug that delivers the therapy to cancer cells and a radioactive particle. In the case of  177 Lu-PSMA-617, the delivery vehicle is PSMA-617, a drug that latches onto a protein called PSMA that is often found at high levels on the surface of prostate cancer cells. The radioactive component is lutetium-177, which is being tested as a part of multiple radiopharmaceutical drugs.

As Dr. Morris explained, PSMA-617 is extremely adept at finding and locking on to the PSMA protein on cells. Once it binds to PSMA on a cancer cell, “the whole molecule is internalized by the cell and the cell is exposed to a lethal dose of radiation” from lutetium-177, he said.

The PSMA protein is also at the heart of a new type of imaging procedure called PSMA PET. This form of PET imaging is just starting to be used in men with prostate cancer to determine whether their cancer has spread, or metastasized, beyond the prostate. In the last several months, FDA has approved two such drugs, known as radiotracers, for PSMA PET imaging. (See box.)

 

Two Agents Approved for PSMA-PET in Prostate Cancer

On May 26, FDA approved piflufolastat F 18 (Pylarify) for use in a type of imaging procedure called PSMA PET in people with prostate cancer. The approval covers the use of piflufolastat F 18 in patients suspected of having metastatic prostate cancer or recurrent prostate cancer (prostate cancer that has returned after treatment). Last year, the agency approved another imaging agent for PSMA PET, Ga 68 PSMA-11, for the same uses, but its use is largely limited to the two institutions where it is made.

In a statement, Lantheus, which manufactures piflufolastat F 18, said the imaging agent “will be immediately available in parts of the mid-Atlantic and southern regions … with broad availability across the U.S. anticipated by year end.” PSMA is often overproduced by prostate cancer cells but is generally not produced by most normal cells, “making it an excellent target for both PET imaging and targeted systemic radiation therapy” like  177 Lu-PSMA-617, Dr. Morris said.

 

Improved Survival, Largely Safe for Patients

The VISION trial enrolled 831 people with metastatic castration-resistant prostate cancer. All of them had previously been treated with chemotherapy and other standard treatments, such as enzalutamide (Xtandi) and  abiraterone (Zytiga). In addition, all participants had PSMA positive tumors—that is, their tumors overproduced PSMA—as determined by PSMA PET imaging.

Trial participants were randomly assigned to receive treatment with  177 Lu-PSMA-617 (up to 6 doses) along with their physician’s choice of treatment, which had to be among several commonly used options for cancers no longer responding to other established treatments, or their physician’s treatment choice alone.

Physicians’; choices of treatment could not include chemotherapy or radium-223 (Xofigo), a radiopharmaceutical specifically used to treat bone metastases in patients with prostate cancer. The typical options included enzalutamide or abiraterone (whichever the patient had not received prior to enrolling in the trial) as well as palliative treatments, like radiation and steroids, Dr. Morris explained in an interview. Under the trial’s design, doctors could adapt treatment as they felt necessary.

“We were trying to mirror [treatment] practices in this particular context,” he said. “If the patient needed a change, they could go from one treatment to another.”

In addition to improving how long patients lived overall, participants treated with  177 Lu-PSMA-617 also had improved progression-free survival, which is how long somebody lives without their cancer getting worse: 8.7 months versus 3.4 months. If approved by FDA, Dr. Morris said,  177 Lu-PSMA-617 “should become a standard of care for these patients, because there are so few existing treatments that prolong their lives.”